Personalized cardiac modeling and simulations in euHeart

euHeart: personalized and integrated cardiac care using patient-specific cardiovascular modelling.

The loss of cardiac pump function accounts for a significant increase in both mortality and morbidity in Western society, where there is currently a one in four lifetime risk, and costs associated with acute and long-term hospital treatments are accelerating. The significance of cardiac disease has motivated the application of state-of-the-art clinical imaging techniques and functional signal a...

Adaptive Tetrahedral Meshing for Personalized Cardiac Simulations

Personalized simulation for therapy planning in the clinical routine requires fast and accurate computations. Finite-element (FE) simulations belong to the most commonly used approaches. Based on medical images the geometry of the patient’s anatomy must be faithfully represented and discretized in a way to find a reasonable compromise between accuracy and speed. This can be achieved by adapting...

[Mathematical modeling and simulations to study cardiac arrhythmias].

Human Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine

Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...

Human Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine

Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...